All of The Union's scientific departments are very active in Africa: TB and HIV, Lung Health and NCDs, Tobacco Control and Research.

The Union Uganda Office: In October 2007, The Union officially opened its first country-based office in sub-Saharan Africa. The office is located in the newly renovated National Tuberculosis and Leprosy Programme (NTLP) building. It manages the TB REACH project.

The Union Zimbabwe Office in Harare coordinates the TB CARE programme there and manages other TB/HIV activities.